Jundishapur Journal of Health Sciences

Published by: Kowsar

Acute Aerobic Exercise and Plasma Levels of Orexin A, Insulin, Glucose, and Insulin Resistance in Males With Type 2 Diabetes

Ali Akbar Alizadeh 1 , * , Farhad Rahmani-Nia 1 , Hamid Mohebbi 1 and Mehrnoosh Zakerkish 2
Authors Information
1 Department of Exercise Physiology, Faculty of Physical Education and Sport Science, University of Guilan, Rasht, IR Iran
2 Department of Endocrinology and Metabolism, Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Health Sciences: January 2016, 8 (1); e32217
  • Published Online: January 9, 2016
  • Article Type: Research Article
  • Received: August 9, 2015
  • Revised: September 21, 2015
  • Accepted: October 21, 2015
  • DOI: 10.17795/jjhs-32217

To Cite: Alizadeh A A, Rahmani-Nia F, Mohebbi H, Zakerkish M. Acute Aerobic Exercise and Plasma Levels of Orexin A, Insulin, Glucose, and Insulin Resistance in Males With Type 2 Diabetes, Jundishapur J Health Sci. 2016 ;8(1):e32217. doi: 10.17795/jjhs-32217.

Abstract
Copyright: Copyright © 0, Jundishapur Journal of Health Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Global Health Estimates: Deaths by Cause, Age, Sex and Country, 2000-2012. 2014;
  • 2. Global status report on noncommunicable diseases WHO. Global status report on noncommunicable diseases 2014. 2014;
  • 3. Olshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005; 352(11): 1138-45[DOI][PubMed]
  • 4. Marino JS, Xu Y, Hill JW. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab. 2011; 22(7): 275-85[DOI][PubMed]
  • 5. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A. 1998; 95(1): 322-7[PubMed]
  • 6. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998; 92(5): 1 page following 696[PubMed]
  • 7. Langmead CJ, Jerman JC, Brough SJ, Scott C, Porter RA, Herdon HJ. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004; 141(2): 340-6[DOI][PubMed]
  • 8. Tsuneki H, Murata S, Anzawa Y, Soeda Y, Tokai E, Wada T, et al. Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice. Diabetologia. 2008; 51(4): 657-67[DOI][PubMed]
  • 9. Martins PJ, D'Almeida V, Pedrazzoli M, Lin L, Mignot E, Tufik S. Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity. Regul Pept. 2004; 117(3): 155-8[PubMed]
  • 10. Tsuneki H, Wada T, Sasaoka T. Role of orexin in the central regulation of glucose and energy homeostasis. Endocr J. 2012; 59(5): 365-74[PubMed]
  • 11. Sakurai T. Roles of orexins in regulation of feeding and wakefulness. Neuroreport. 2002; 13(8): 987-95[PubMed]
  • 12. Nishino S, Sakurai T. The orexin /hypocretin system Physiology and Pathophysiology. 2006;
  • 13. Weltman A, Pritzlaff CJ, Wideman L, Considine RV, Fryburg DA, Gutgesell ME, et al. Intensity of acute exercise does not affect serum leptin concentrations in young men. Med Sci Sports Exerc. 2000; 32(9): 1556-61[PubMed]
  • 14. Wu MF, John J, Maidment N, Lam HA, Siegel JM. Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am J Physiol Regul Integr Comp Physiol. 2002; 283(5)-86[DOI][PubMed]
  • 15. Messina G, Di Bernardo G, Messina A, Dalia C, Chieffi S. Brief Exercise Enhances Blood Hypocretin-1 in Sedentary Men. J Sports Med Doping Stud. 2014; 4(149): 2161-673.1000149
  • 16. Bruce RA, Lovejoy FJ, et al. Normal respiratory and circulatory pathways of adaptation in exercise. J Clin Invest. 1949; 28(6 Pt 2): 1423-30[DOI][PubMed]
  • 17. Weir JB. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol. 1949; 109(1-2): 1-9[PubMed]
  • 18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28(7): 412-9[PubMed]
  • 19. Espana RA, McCormack SL, Mochizuki T, Scammell TE. Running promotes wakefulness and increases cataplexy in orexin knockout mice. Sleep. 2007; 30(11): 1417-25[PubMed]
  • 20. Jochem J, Zwirska-Korczala K, Zabielski R, Kato I, Kuwahara A. Cardiovascular effects of centrally acting orexin A in haemorrhage-shocked rats. J Physiol Pharmacol. 2006; 57 Suppl 11: 115-24[PubMed]
  • 21. Huang SC, Dai YW, Lee YH, Chiou LC, Hwang LL. Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors. J Pharmacol Exp Ther. 2010; 334(2): 522-9[DOI][PubMed]
  • 22. Wu MF, Nienhuis R, Maidment N, Lam HA, Siegel JM. Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes. Arch Ital Biol. 2011; 149(4): 492-8[DOI][PubMed]
  • 23. Shahid IZ, Rahman AA, Pilowsky PM. Orexin and central regulation of cardiorespiratory system. Vitam Horm. 2012; 89: 159-84[DOI][PubMed]
  • 24. Mizuno A, Murakami T, Otani S, Kuwajima M, Shima K. Leptin affects pancreatic endocrine functions through the sympathetic nervous system. Endocrinology. 1998; 139(9): 3863-70[DOI][PubMed]
  • 25. Wang J, Osaka T, Inoue S. Orexin-A-sensitive site for energy expenditure localized in the arcuate nucleus of the hypothalamus. Brain Res. 2003; 971(1): 128-34[PubMed]
  • 26. Skrzypski M, T. Le T , Kaczmarek P, Pruszynska-Oszmalek E, Pietrzak P, Szczepankiewicz D, et al. Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes. Diabetologia. 2011; 54(7): 1841-52[DOI][PubMed]
  • 27. Jamurtas AZ, Theocharis V, Koukoulis G, Stakias N, Fatouros IG, Kouretas D, et al. The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males. Eur J Appl Physiol. 2006; 97(1): 122-6[DOI][PubMed]
  • 28. Rodnick KJ, Henriksen EJ, James DE, Holloszy JO. Exercise training, glucose transporters, and glucose transport in rat skeletal muscles. Am J Physiol. 1992; 262(1 Pt 1)-14[PubMed]
  • 29. Tjonna AE, Lee SJ, Rognmo O, Stolen TO, Bye A, Haram PM, et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation. 2008; 118(4): 346-54[DOI][PubMed]
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