Jundishapur Journal of Health Sciences

Published by: Kowsar

Protective Effects of Zinc Supplementation on Renal Toxicity in Rats Exposed to Cadmium

Raziyeh Morshedi 1 , Massumeh Ahmadizadeh 1 , 2 , * and Kambiz Ahmadi Angali 3
Authors Information
1 Department of Occupational Health, Engineering, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Department of Statistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Health Sciences: August 01, 2014, 6 (3); e21717
  • Published Online: July 26, 2014
  • Article Type: Research Article
  • Received: April 21, 2014
  • Revised: May 25, 2014
  • Accepted: June 2, 2014
  • DOI: 10.5812/jjhs.21717

To Cite: Morshedi R, Ahmadizadeh M, Ahmadi Angali K. Protective Effects of Zinc Supplementation on Renal Toxicity in Rats Exposed to Cadmium, Jundishapur J Health Sci. 2014 ; 6(3):e21717. doi: 10.5812/jjhs.21717.

Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Godt J, Scheidig F, Grosse-Siestrup C, Esche V, Brandenburg P, Reich A, et al. The toxicity of cadmium and resulting hazards for human health. J Occup Med Toxicol. 2006; 1: 22[DOI][PubMed]
  • 2. DN W. Cadmium. 1988; : 9-16
  • 3. Wang B, Luo Q, Shao C, Li X, Li F, Liu Y, et al. The late and persistent pathogenic effects of cadmium at very low levels on the kidney of rats. Dose Response. 2013; 11(1): 60-81[DOI][PubMed]
  • 4. Jarup L, Alfven T. Low level cadmium exposure, renal and bone effects--the OSCAR study. Biometals. 2004; 17(5): 505-9[PubMed]
  • 5. Zalups RK, Ahmad S. Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol. 2003; 186(3): 163-88[PubMed]
  • 6. World Health Organization . Environmental Health Criteria 134. 1992;
  • 7. Casalino E, Calzaretti G, Sblano C, Landriscina C. Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology. 2002; 179(1-2): 37-50[PubMed]
  • 8. Jarup L. Cadmium overload and toxicity. Nephrol Dial Transplant. 2002; 17 Suppl 2: 35-9[PubMed]
  • 9. Swiergosz-Kowalewska R. Cadmium distribution and toxicity in tissues of small rodents. Microsc Res Tech. 2001; 55(3): 208-22[DOI][PubMed]
  • 10. Karabulut-Bulan O, Bolkent S, Yanardag R, Bilgin-Sokmen B. The role of vitamin C, vitamin E, and selenium on cadmium-induced renal toxicity of rats. Drug Chem Toxicol. 2008; 31(4): 413-26[DOI][PubMed]
  • 11. Brzoska MM, Moniuszko-Jakoniuk J. Interactions between cadmium and zinc in the organism. Food Chem Toxicol. 2001; 39(10): 967-80[PubMed]
  • 12. Gurbay A. Protective effect of zinc chloride against cobalt chloride-induced cytotoxicity on vero cells: preliminary results. Biol Trace Elem Res. 2012; 148(1): 110-6[DOI][PubMed]
  • 13. Rafique M, Pervez S, Tahir F. Protective effect of zinc over lead toxicity on testes. J Coll Physicians Surg Pak. 2010; 20(6): 377-81[PubMed]
  • 14. Jemai H, Lachkar HA, Messaoudi I, Kerkeni A. Effects of zinc pre-treatment on blood glutathione, serum zinc and kidney histological organisation in male rats exposed to cadmium. J Trace Elem Med Biol. 2010; 24(4): 277-82[DOI][PubMed]
  • 15. Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta. 1978; 90(1): 37-43[PubMed]
  • 16. Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure--a review of the literature and a risk estimate. Scand J Work Environ Health. 1998; 24 Suppl 1: 1-51[PubMed]
  • 17. Brzoska MM, Moniuszko-Jakoniuk J. The influence of calcium content in diet on cumulation and toxicity of cadmium in the organism. Arch Toxicol. 1998; 72(2): 63-73[PubMed]
  • 18. Al-Attar AM. Antioxidant effect of vitamin E treatment on some heavy metals-induced renal and testicular injuries in male mice. Saudi J Biol Sci. 2011; 18(1): 63-72[DOI][PubMed]
  • 19. Rikans LE, Yamano T. Mechanisms of cadmium-mediated acute hepatotoxicity. J Biochem Mol Toxicol. 2000; 14(2): 110-7[PubMed]
  • 20. Esrefoglu M, Gul M, Dogru MI, Dogru A, Yurekli M. Adrenomedullin fails to reduce cadmium-induced oxidative damage in rat liver. Exp Toxicol Pathol. 2007; 58(5): 367-74[DOI][PubMed]
  • 21. Patra RC, Swarup D, Senapati SK. Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic, renal and testicular tissue of rats. Vet Hum Toxicol. 1999; 41(2): 65-7[PubMed]
  • 22. Koyu A, Gokcimen A, Ozguner F, Bayram DS, Kocak A. Evaluation of the effects of cadmium on rat liver. Mol Cell Biochem. 2006; 284(1-2): 81-5[DOI][PubMed]
  • 23. Erdogan Z, Erdogan S, Celik S, Unlu A. Effects of ascorbic acid on cadmium-induced oxidative stress and performance of broilers. Biol Trace Elem Res. 2005; 104(1): 19-32[DOI][PubMed]
  • 24. Jemai H, Messaoudi I, Chaouch A, Kerkeni A. Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium. J Trace Elem Med Biol. 2007; 21(4): 269-73[DOI][PubMed]
  • 25. Kagi JH. Overview of metallothionein. Methods Enzymol. 1991; 205: 613-26[PubMed]
  • 26. Il'yasova D, Schwartz GG. Cadmium and renal cancer Toxicol Appl Pharmacol 2005; 207(2): 179-86
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments